Prognostic Value of Mean Platelet Volume and Neutrophil/lymphocyte Ratio in Patients with Pulmonary Embolism

Introduction: We compared the prognostic values of mean platelet volume (MPV) and neutrophil/lymphocyte (NLR) between surviving and nonsurviving patients with pulmonary embolism (PE). Materials and methods: A total of 156 patients were screened by I26 code of ICD-9 and 89 patients were included as cases of confirmed PE. Admission blood counts and clinical data were obtained from hospital records. We further classified the PE patients into 2 groups: those who survived and those who died in the first 30 days. NLR and MPV were measured in serum and compared between the groups. Results: MPV was significantly higher among patients of nonsurviving group when compared with surviving one (8.7 ± 0.1vs 7.5 ± 0.3 fL, respectively; P < 0.001). NLR values were significantly higher in non-survivor group compared with the survivors (12,69 ± 1,87 vs 6,34 ± 0,66, respectively; P < 0.001). There was a statistically correlation between MPV and mean pulmonary arterial pressure (r = 0.50, p < 0.001) and also between MPV and right ventricle diameter (RVD) (r = 0.68, p < 0.001). In addition our result showed that a correlation between NLR and RVD (r = 0.43, p < 0.001) and also a correlation between NLR and systolic pulmonary arterial pressure (r = 0.31, p =0.003). Discussion: Since complete blood count is a part of the routine laboratory investigation in the most hospitalised patients use and preliminary promising results of this study, NLR and MPV should be investigated in future prospective randomised trials regarding prognostic value in acute PE.